Electrophysiological alterations driving pain-associated spontaneous activity in human sensory neuron somata parallel alterations described in spontaneously active …
Neuropathic pain in rodents can be driven by ectopic spontaneous activity (SA) generated
by sensory neurons in dorsal root ganglia (DRG). The recent demonstration that SA in
dissociated human DRG neurons is associated with reported neuropathic pain in patients
enables a detailed comparison of pain-linked electrophysiological alterations driving SA in
human DRG neurons to alterations that distinguish SA in nociceptors from SA in low-
threshold mechanoreceptors (LTMRs) in rodent neuropathy models. Analysis of recordings …
by sensory neurons in dorsal root ganglia (DRG). The recent demonstration that SA in
dissociated human DRG neurons is associated with reported neuropathic pain in patients
enables a detailed comparison of pain-linked electrophysiological alterations driving SA in
human DRG neurons to alterations that distinguish SA in nociceptors from SA in low-
threshold mechanoreceptors (LTMRs) in rodent neuropathy models. Analysis of recordings …
