Drugs to reduce bleeding and transfusion in major open vascular or endovascular surgery: a systematic review and network meta‐analysis
A Beverly, G Ong, C Kimber… - Cochrane Database …, 2023 - cochranelibrary.com
Cochrane Database of Systematic Reviews, 2023•cochranelibrary.com
Background Vascular surgery may be followed by internal bleeding due to inadequate
surgical haemostasis, abnormal clotting, or surgical complications. Bleeding ranges from
minor, with no transfusion requirement, to massive, requiring multiple blood product
transfusions. There are a number of drugs, given systemically or applied locally, which may
reduce the need for blood transfusion. Objectives To assess the effectiveness and safety of
anti‐fibrinolytic and haemostatic drugs and agents in reducing bleeding and the need for …
surgical haemostasis, abnormal clotting, or surgical complications. Bleeding ranges from
minor, with no transfusion requirement, to massive, requiring multiple blood product
transfusions. There are a number of drugs, given systemically or applied locally, which may
reduce the need for blood transfusion. Objectives To assess the effectiveness and safety of
anti‐fibrinolytic and haemostatic drugs and agents in reducing bleeding and the need for …
Background
Vascular surgery may be followed by internal bleeding due to inadequate surgical haemostasis, abnormal clotting, or surgical complications. Bleeding ranges from minor, with no transfusion requirement, to massive, requiring multiple blood product transfusions. There are a number of drugs, given systemically or applied locally, which may reduce the need for blood transfusion.
Objectives
To assess the effectiveness and safety of anti‐fibrinolytic and haemostatic drugs and agents in reducing bleeding and the need for blood transfusion in people undergoing major vascular surgery or vascular procedures with a risk of moderate or severe (> 500 mL) blood loss.
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